Cynanchum Atratum Extract yog dab tsi?
Cynanchum atratum extract (Apocynaceae) yog cov tshuaj pej xeem los kho cov kab mob ntawm daim tawv nqaij. Txawm li cas los xij, cov teebmeem ntawmcynanchum atratum extractntawm atopic dermatitis tsis tau piav qhia.
Hauv txoj kev tshawb no, peb ntsuas qhov cuam tshuam ntawm aqueous extract ntawm cynanchum atratum extract rau ntawm daim tawv nqaij thiab nws cov txheej txheem molecular ntawm atopic dermatitis (AD). 1 thiab 100mg/mL cynanchum atratum extract hmoov tau pleev xim rau 2, 4-dinitrochlorobenzene (DNCB)-induced AD-zoo li daim tawv nqaij mob rau 11 hnub. Tus naj npawb ntawm khawb tus cwj pwm raug soj ntsuam rau 20 feeb. Cov tsos mob zoo li AD suav nrog cov ntshav siab IgE, daim tawv nqaij hyperplasia thiab mast cell infiltration tau tshawb xyuas.
Cov ntaub ntawv tseem ceeb:
| Khoom npe | Cynanchum Atratum Essence |
| Lwm lub npe | Cynanchum Atratum Extract |
| Solubility | Dej Soluble |
| Cov khoom xyaw nquag | Cynanchum Atratum glycosides, alkaloids |
| Qib | Qib tshuaj pleev ib ce |
| Txoj Kev Xeem | Ntsuam xyuas qhov loj ntawm cov khoom seem tom qab cov kua evaporated ntawm qhov kub ntawm 102 ° C rau 1 teev |
| Txheej txheem khiav | Cawv extraction-ntau yam extraction-chromatographic cais |
| Muaj nuj nqi | Kev tu tawv nqaij |
| Kev siv | Kev siv sab nraud |
| Daim ntawv thov | Ntxuav thiab tu cov khoom, xws li tshuaj pleev, qhov ncauj qhov ntswg, cream, tshuaj ntxuav lub ntsej muag, tshuaj pleev ib ce, plaub hau tu essences, thiab lwm yam. |
Cynanchum Atratum Extract Cov txiaj ntsig:
Cynanchum atratum extract (Apocynaceae) yog ib hom tshuaj kho mob ntawm daim tawv nqaij. Txawm li cas los xij, qhov cuam tshuam ntawm C. atratum ntawm atopic dermatitis tsis tau qhia meej. Hauv qhov kev tshuaj xyuas no, peb ntsuas qhov cuam tshuam ntawm cov kua dej concentrate ntawm cynanchum atratum extract thiab nws cov sub-atomic tivthaiv ntawm atopic dermatitis (Promotion).
1 thiab 100 mg/mL cynanchum atratum extract rau ntawm daim tawv nqaij tau pleev xim rau 2, 4-dinitrochlorobenzene (DNCB)- instigated Promotion zoo li daim tawv nqaij mob rau 11 hnub. Qhov kom muaj nuj nqis ntawm khawb kev coj ua tau raug soj ntsuam rau 20 min. Kev txhawb nqa zoo li cov kev mob tshwm sim suav nrog cov ntshav nce siab IgE, daim tawv nqaij hyperplasia thiab ncej cell ntxeem tau raug tshawb nrhiav. Cov nqe lus ntawm kev pom zoo rau provocative cytokines thiab mus nruab nrab tau tawg nyob rau hauv Promotion zoo li daim tawv nqaij armies. Ntxiv mus, qhov ua tau zoo rau kev tsim cov cytokine tau lees paub hauv tib neeg ncej hlwb (HMC)- 1 animated nrog PMA ntxiv rau A23187 (PMACI). Kev siv tau zoo ntawm cynanchum atratum extract rau ntawm daim tawv nqaij constricted ua tiav cov ntshav qib IgE thiab khawb kev coj ua.
Cov tawv nqaij hyperplasia suav nrog epidermis thiab dermis tau txhim kho nyob rau hauv cynanchum atratum extract-kho tawv tub rog. Qhov kom muaj nuj nqis ntawm cov hlwb nkag mus tau qhov tseem ceeb txo qis los ntawm kev kho CA. Tsis tas li ntawd, cynanchum atratum extract hmoov txo qis kev txhawb nqa ntawm cytokines fiery, piv txwv li, IL-6, IL-1 thiab TNF- thiab Th2 cytokine, IL-4, nyob rau hauv ob qho tib si ntawm Promotion zoo li daim tawv nqaij mob thiab PMACI-sharpened HMC-1 hlwb. Tsis tas li ntawd, CA txo qis cov nqe lus ntawm NF-κB, phospho-IκB thiab Guide kinase. Cov txiaj ntsig no pom zoo kom muaj kev cuam tshuam txog kev cuam tshuam ntawm CA ntawm kev txhim kho ntawm Kev Tshaj Tawm los ntawm kev qhia kev txhawb nqa ntawm incendiary cytokines thiab cov neeg nruab nrab. CA tuaj yeem yog cov khoom muaj zog rau kev kho mob ntawm Kev Tshaj Tawm.
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