Ellagic Acid

Ellagic Acid yog dab tsi?

Ellagic acid yog lub qhov dej zoo ntawm ellagic corrosive (EA), ellagitannins (ETs), anthocyanins thiab ntau yam phytochemicals. Kev kho mob zoo ntawmpomegranate(Pom) tau txuas nrog nws cov ntsiab lus EA thiab ET. Lub hom phiaj ntawm qhov kev tshuaj xyuas tam sim no yog txiav txim siab EA bioavailability thiab bioactivity los ntawm ntau qhov chaw, piv txwv li, unadulterated / dawb lossis tsis tu ncua qauv (PomJ). Qhov no yog kev kawm dhau los nrog cov neeg ua haujlwm ruaj khov uas tau txais ib feem ntawm EA kev noj zaub mov kom zoo (500 mg dawb EA) piv rau ib qho kev pabcuam PomJ (237 mL, ∼120 mg ntawm EA) hauv qhov kev thov tsis tu ncua.

Peb cov ntaub ntawv qhia tias tsis muaj qhov sib txawv hauv plasma EA fixation ntawm ellagic acid thiab EA nkag; Txawm li cas los xij, urinary dimethylellagic corrosive glucuronide (DMEAG), tus qauv rau creatinine, yog qhov tseem ceeb dua tom qab kev siv PomJ sib piv nrog EA. Plasma insulin ntawm 1 h nthuav dav tom qab kev siv ellagic acid sib piv nrog cov qauv thaum txo qis tom qab kev siv EA sib piv nrog tus qauv.

Cov ntaub ntawv tseem ceeb:

Cov txiaj ntsig ntawm Ellagic Acid:

Cov qib siab tshaj plaws ntawm ellagic acid yog taug qab hauv pomegranates thiab txiv hmab txiv ntoo. Cov tshuaj tiv thaiv kabmob kheesxaws ntawm ellagic acid tau raug txheeb xyuas. Ib yam li ntawd, ellagic acid plays ib qho kev txo qis hauv kev kho mob ulcerative colitis tas li kom tsis txhob muaj kev txhim kho ntawm txoj hnyuv loj.

Cov kws tshawb fawb kuj tau pom zoo tias ellagic acid yog qhov muaj peev xwm tiv thaiv oxidative siab. Kao et al. tau qhia txog qhov cuam tshuam loj ntawm ellagic acid ntawm ntau hom CRC cell. Nws yuav tsum raug pom tias txoj hauv kev ntawm PI3K / Akt suav tias yog ib feem tseem ceeb ntawm kev loj hlob pib hauv txoj hnyuv thiab ellagic corrosive tuaj yeem tswj xyuas cov kab mob qog nqaij hlav hauv plab los ntawm cov kab ke nrog rau kev cuam tshuam ntawm Akt phosphorylation ntawm Ser473. Qhov tseem ceeb, cov nyhuv inhibitory ntawm ellagic corrosive ntawm Akt phosphorylation tau pom hauv lwm qhov kev tshuaj xyuas.

Cov kws tshawb fawb tau tshaj tawm tias ellagic acid thiab nws cov metabolites tuaj yeem txwv CaCo-2 (Caco-2 cell kab yog ib lub xov tooj ntawm tes tsis tu ncua ntawm heterogeneous human epithelial colonectal adenocarcinoma cell) nthuav tawm los ntawm lub voj voog ntawm tes. Peb xav tias kev siv cov kua txiv hmab txiv ntoo thiab pomegranate muaj kev kho thiab tiv thaiv cov teebmeem hauv CRC. Peb xav tias yuav tsum tau soj ntsuam ntxiv kom tau txais txiaj ntsig sib txawv ntawm ellagic acid thiab siv cov txiaj ntsig loj hauv kev tshawb nrhiav kev noj qab haus huv ntawm kev noj qab haus huv thiab kev txo qis ntawm CRC.

Daim ntawv thov Ellagic Acid:

1.Nws tuaj yeem siv rau hauv kev tsim cov tshuaj thiab cov khoom noj qab haus huv

2.Nws tuaj yeem siv rau hauv cov khoom noj khoom haus ntxiv

3.Nws tuaj yeem siv rau hauv kev tsim cov tshuaj pleev ib ce

Qhov zoo tshaj plaws ellagic acid tsum

Undersun tshwj xeeb hauv ellagic acid tau ntau xyoo, peb muab cov khoom lag luam nrog cov nqi sib tw, thiab peb cov khoom yog cov khoom zoo tshaj plaws thiab ua tiav kev soj ntsuam nruj, ywj siab los xyuas kom meej tias nws muaj kev nyab xeeb rau kev noj thoob ntiaj teb.