Shikimic Acid

Shikimic Acid yog dab tsi?

Ib qho khoom lag luam tseem ceeb hauv ntuj, shikimic acid yog siv los ua Tamiflu precursor. Niaj hnub no, nws yog tsim los ntawm fermenting lub hnub qub anise (Illicium verum) los yog los ntawm extracting nws nyob rau hauv ntau pua txhiab tons. Ntxiv nrog rau nws siv hauv kev tsim cov Tamiflu, acid shikimic tau txais kev tsis txaus siab vim nws qhov kev thov dav dav raws li ntau yam chiral precursor hauv cov organic synthesis vim nws qhov muaj txiaj ntsig chirality thiab cov txiaj ntsig zoo ntawm cov pob txha.

Qhov kev tshuaj xyuas no qhia txog qee txoj hauv kev rau kev cais tawmShikimic acidlos ntawm cov chaw cog thiab muab cov ntsiab lus ntawm lub ntsiab hluavtaws thiab microbial txoj kev rau nws cov khoom. Los ntawm kev npog cov kev hloov pauv tseem ceeb tshaj plaws thiab cov ntaub ntawv ntsig txog, suav nrog kev sib xyaw ntawm tamiflu shikimic acid thiab derivatives, hluavtaws manipulations ntawm pawg neeg ua haujlwm tseem ceeb, thiab nws siv los ua cov khoom siv biorenewable thiab tag nrho cov khoom siv hluavtaws, peb kuj tau sim ua kom pom cov khoom siv hluavtaws. ntawm shikimic acid.

Cov ntaub ntawv tseem ceeb:

Cov txiaj ntsig ntawm Shikimic Acid:

1. Antibacterial thiab antitumor

Shikimic acid derivatives muaj cov tshuaj tua kab mob thiab tshuaj tua kab mob. Xyoo 1987, cov kws tshawb fawb Nyij Pooj tau tshawb pom tias cov analogs ntawm glyoxalase I inhibitors tau tsim los ntawm methyl shikimate tau pom tseeb cuam tshuam rau HeLa cell kab thiab Echley ascites carcinoma, thiab tuaj yeem ua kom ntev lub sij hawm ciaj sia ntawm cov nas inoculated nrog leukemia hlwb L1210, thiab cov toxicity kuj tsawg. , thiab nws cov nyhuv inhibitory feem ntau cuam tshuam nrog cov tshuaj tiv thaiv hydrogen sulfide. Xyoo 1988, Suav cov kws tshawb fawb tau tsim cov tshuaj shikimic acid derivative, uas ua pov thawj tias cov tshuaj no muaj cov nyhuv inhibiting leukemia cell L1210 hauv vitro.

2. Anti-thrombosis

Cov teebmeem ntawm acid shikimic thiab nws cov derivatives ntawm cov hlab plawv system yog manifested nyob rau hauv antithrombotic thiab antiplatelet aggregation teebmeem. Kev tshawb fawb tau pom tias shikimic acid muaj zog inhibitory nyhuv ntawm platelet aggregation tus nqi ntawm adenosine diphosphate-induced nruab nrab cerebral artery embolism qauv nas; ob leeg txhaj tshuaj thiab intramuscular txhaj ntawm shikimic acid tuaj yeem ua kom lub sijhawm ntev ntawm cov ntshav coagulation ntawm nas.

3. Anti-cerebral ischemia

Tamiflu shikimic acid thiab nws cov derivatives muaj cov txiaj ntsig ntawm kev txhim kho cerebral ischemia, feem ntau yog txo qhov ntim ntawm cerebral infarction tom qab focal cerebral ischemia hauv nas, txo cov qhab nia ua haujlwm neurological, txo cov qib ntawm cerebral edema, thiab ua rau cov ntshav cerebral txaus hauv cov cheeb tsam ischemic thiab. lwm yam ntsuas. Cov kev tshawb fawb tau pom tias nws cov derivatives tuaj yeem txo cov qib ntawm cov ntshav liab sib sau ua ke tom qab cerebral ischemia thiab inhibit platelet aggregation, yog li muaj txiaj ntsig zoo rau cerebral microcirculation.

Kev siv Shikimic Acid:

1. Nws cov nyhuv pharmacological ntau, nws aslo siv los ua tshuaj kho mob;

2. Siv nyob rau hauv cov zaub mov, raws li raw cov ntaub ntawv ntawm cov khoom noj khoom haus tau tshwm sim nyob rau hauv lub lag luam.

Tiv tauj peb:

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