Oleander Extract CancerEffects
Oleandrin thiab oleandrigenin yog ob yam khoom xyaw ntawm Oleander muaj cov Antitumor kev ua haujlwm zoo tiv thaiv prostate cancer cell kabCov. Anvirzel thiab oleandrin tuaj yeem ua rau tib neeg mob cell tuag taus. Cov kev tshawb fawb soj ntsuam tau ua rauoleander extractqhia tias cov tshuaj ntsuab no ua raws li tus neeg sawv cev anticancer. Lub cev sib xyaw ua ke Oleandrin thiab oleandrigenin muaj cov khoom anticancerous. Anvirzel yog ib yam muaj tshuaj lom nyob hauv cov nroj no tuaj yeem ua rau mob apoptosis, uas ua rau mob cancer cell tuag.
Lub hom phiaj ntawm txoj kev tshawb no yog txhawm rau tshuaj xyuas cov txheej txheem (s) thiab kev sib txawv ntawm lub cev-tua cov teebmeem ntawm Anvirzel, ib qho kev rho tawm ntawm oleander (Nerium oleander; tsev neeg-Apocynaceae), thiab nws cov derivative compound Oleandrin rau tib neeg, canine thiab tua neeg mob qog nqaij hlav. Cov hlwb tau txais ntau qhov sib txawv ntawm Anvirzel (1.0 ng / ml txog 500 microg / ml) lossis Oleandrin (0.01 ng / ml txog 50 microg / ml) hauv kev kho thiab tev naus-kho / rov zoo sib xws. Lub cytotoxicity ntawm cov tebchaw tau txiav txim siab.
Ob qho Anvirzel thiab Oleandrin tau muaj peev xwm ntxias cov cell hauv tib neeg mob hlwb, tab sis tsis yog tua cov hlwb mob hlwb; lub cell-tua potency ntawm Oleandrin yog ntau dua li ntawm Anvirzel. Canine qhov ncauj mob qog nqaij hlav kho nrog Anvirzel qhia cov theem ntawm cov lus teb theem nrab, nrog qee cov kabmob metaphases thiab ntawm tes tuag los ntawm kev kho mob. Los ntawm cov txiaj ntsig no peb xaus lus tias Anvirzel thiab Oleandrin ua yam ntxwv ntawm hom tsiaj, thiab thaum kuaj qhov ua tau zoo ntawm cov tshuaj sib txuas tshiab rau kev kho mob qog noj ntshav, ib qho yuav tsum siv tsis tsuas tua neeg tab sis ntau yam mob hlwb, suav nrog tib neeg keeb kwm.
Oleander extract mob cancer tuaj yeem ua rau cov qog nce zuj zus los ntawm kev txwv cov qog ua enzyme Na {{0}}, K+ -ATPase, tshwj xeeb tshaj yog nyob rau hauv cov hlwb uas muaj qhov sib piv siab ntawm alpha 3 rau alpha 1 isoform qhia. Nws txhim kho cov cellular export ntawm fibroblast kev loj hlob tau-2.Oleandrinkuj tseem ua rau apoptosis los ntawm NF-kB kev tsuj. Nws xaiv tau mob ntsws ntsws mob hlwb rau apoptosis-inducing ligand Apo2L / Kev ntawm DR4 / 5 upregulation ntawm RNA thiab qib protein ntau. Lwm qhov kev tawm tswv yim suav nrog kev tsim ntawm superoxide radicals uas ua rau cov qog xovtooj ntawm kev raug mob ntawm mitochondrial cuam tshuam, IL-8 inhibition uas kho cov nqaij hlav rau lub cev, kev ua haujlwm ntawm caspase-3, induction ntawm qog cell autophagy, thiab P-gp inhibition. Ntau tsis ntev los no, PBI-05204, ib qho kev nthuav tawm ntawm N. oleander, inhibited pancreatic qog nqaij hlav loj zuj zus ib nrab ntawm downregulation ntawm PI3k / Akt thiab mTOR txoj kev.
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