Dab tsi yog monacolin k
Monacolin Ktau raug teev raws li cov khoom noj khoom haus hauv RYR npaj uas yog lub luag haujlwm rau kev thov cov txiaj ntsig ntawm kev saib xyuas cov ntshav LDL-cholesterol ntau npaum li cas. Hauv kev ntsuam xyuas kev nyab xeeb ntawm monacolins, Pawg Neeg Saib Xyuas tau suav tias yog monacolin K thiab lovastatin zoo ib yam, tom kawg yog cov khoom xyaw nquag ntawm cov tshuaj tau tso cai hauv EU rau kev kho mob hypercholesterolemia. Lub Vaj Huam Sib Luag tau sau tseg tias hauv daim ntawv thov kev noj qab haus huv (EFSA NDA Vaj Huam Sib Luag, 2013), kev noj cov tshuaj monacolin K yog 10 mg / hnub rau kev saib xyuas cov ntshav li qub LDL-cholesterol. Qhov kev noj tshuaj ntawm monacolin K sib tshooj ntawm cov tshuaj kho qis tshaj plaws ntawm 10 mg / hnub ntawm lovastatin qhia raws li qhov pib koob tshuaj rau kev kho mob hypercholesterolemia (SPC rau lovastatin, online).
Cov txiaj ntsig ntawm lwm cov khoom xyaw ua tau ntawm cov khoom noj ntxiv ntawm monacolins bioactivity tsis suav nrog hauv qhov kev xav no.
Monacolin k ua haujlwm li cas
Liab poov movyog tsim los ntawm culturing mov nrog ntau hom ntawm cov poov xab Monascus purpureus. Qee qhov kev npaj ntawm cov poov xab liab yog siv rau hauv cov khoom noj khoom haus hauv Suav zaub mov, suav nrog Peking os. Lwm tus tau raug muag raws li kev noj zaub mov kom txo qis cov roj cholesterol thiab lwm yam lipids.
Qee cov khoom lag luam poov xab liab muaj cov tshuaj hu ua monacolins, uas yog tsim los ntawm cov poov xab. Monacolin K yog tshuaj zoo ib yam rau cov khoom muaj nyob rau hauv cov tshuaj txo cov roj cholesterol lovastatin, uas yog ib qho ntawm cov tshuaj hauv qeb hu ua statins. Cov tshuaj no txo cov roj cholesterol los ntawm kev txo cov roj cholesterol los ntawm lub siab.
Cov khoom xyaw ntawm cov poov xab liab cov khoom sib txawv nyob ntawm seb hom poov xab thiab kab lis kev cai siv los tsim lawv. Cov kab mob thiab cov xwm txheej siv los tsim cov poov xab liab liab txawv ntawm cov khoom siv los tsim cov khoom tsim los txo cov roj cholesterol. Cov kev ntsuam xyuas ua los ntawm FDA qhia tias cov poov xab liab muag raws li cov khoom noj khoom haus tsuas muaj cov kab mob monacolin K lossis tsis muaj dab tsi.
Cov khoom noj dab tsi muaj monacolin k
Qee cov khoom lag luam poov xab liab muaj ntau ntau ntawm monacolin K, uas yog tshuaj zoo ib yam rau cov khoom muaj nyob hauv cov tshuaj lovastatin txo cov roj cholesterol. Cov khoom no tuaj yeem txo cov roj (cholesterol) hauv cov ntshav thiab tuaj yeem ua rau tib hom kev phiv thiab kev cuam tshuam ntawm cov tshuaj xws li lovastatin.
Lwm cov khoom lag luam poov xab liab muaj me me lossis tsis muaj monacolin K. Nws tsis paub tias cov khoom no puas muaj kev cuam tshuam rau cov ntshav cholesterol.
Cov neeg siv khoom tsis muaj txoj hauv kev paub ntau npaum li cas monacolin K muaj nyob hauv cov khoom lag luam poov xab liab. Cov ntawv sau rau ntawm cov khoom no feem ntau hais tsuas yog cov poov xab liab uas lawv muaj, tsis yog cov nyiaj ntawm monacolin K.
US Food and Drug Administration (FDA) tau txiav txim siab tias cov khoom lag luam poov xab liab uas muaj ntau tshaj li cov kab mob ntawm monacolin K yog cov tshuaj tshiab uas tsis tau txais kev pom zoo thiab tsis tuaj yeem muag tau raws cai raws li kev noj haus.
Qee cov khoom lag luam poov xab liab muaj cov kab mob hu ua citrinin, uas tuaj yeem ua rau lub raum tsis ua haujlwm.
Qhia tag nrho koj cov kws kho mob txog txhua yam kev kho mob ntxiv uas koj siv. Muab lawv daim duab tag nrho ntawm qhov koj ua los tswj koj txoj kev noj qab haus huv. Qhov no yuav pab kom muaj kev sib koom tes thiab kev saib xyuas zoo.
Monacolin k ntau npaum li cas hauv cov poov xab liab
Nyob rau hauv ib daim ntawv 2014 luam tawm nyob rau hauv Phau ntawv Journal of Pharmaceutical thiab Biomedical Analysis, cov kws tshawb fawb los ntawm University of Mississippi, Harvard Medical School thiab Tuam Tshoj Food and Drug Administration divulated tus nqi ntawm monacolin K nyob rau hauv cov tshuaj uas sau tias muaj 600 mg ntawm cov poov xab liab ntau ntau. ntau dua 40-fold los ntawm 0.03 mg rau 2.18 mg.
Tias tus nqi ntawm monacolin K txawv ntawm ntau hom tshuaj ntxiv tsis qhia tias cov khoom raug tsim tawm hauv kev ua txhaum cai ntawm FDA.
"Kev hloov pauv hauv cov ntsiab lus ntawm cov khoom siv phytochemical hauv cov khoom noj khoom haus yuav tsum tau cia siab, vim qhov sib txawv ntawm cov khoom siv raw zoo thiab cov txheej txheem tsim khoom yuav cuam tshuam rau qhov muaj pes tsawg leeg," Gafner ntawm ABC piav qhia.
Yog monacolin k nyab xeeb
Lub Vaj Huam Sib Luag tau xaus lus tias kev raug monacolin K los ntawm RYR tuaj yeem ua rau muaj kev cuam tshuam loj heev rau cov kab mob musculoskeletal, suav nrog rhabdomyolysis, thiab ntawm daim siab. Hauv cov ntaub ntawv tshaj tawm, cov khoom lag luam muaj lwm cov khoom xyaw ntxiv rau RYR. Txawm li cas los xij, cov teebmeem no tau tshaj tawm hauv cov teebmeem ntawm cov leeg nqaij, muaj ob qho tib si tshwm sim tom qab noj monacolin K thiab lovastatin ntawm nws tus kheej. Raws li cov ntaub ntawv muaj thiab ntau qhov tsis paub tseeb uas tau hais tseg hauv qhov kev xav no, Pawg Neeg Saib Xyuas tsis tuaj yeem txheeb xyuas qhov kev noj haus ntawm monacolins los ntawm RYR uas tsis ua rau muaj kev txhawj xeeb txog kev phom sij rau kev noj qab haus huv, rau cov pej xeem, thiab raws li qhov tsim nyog, rau cov pab pawg tsis muaj zog ntawm cov pejxeem.
Monacolin k cov txiaj ntsig
Cov roj (cholesterol) siab (hyperlipidemia). Kev tshawb fawb qhia tau hais tias liab poov mov nplej uas muaj ntau npaum li cas ntawm monocolin K tuaj yeem txo koj cov qib roj cholesterol tag nrho, koj cov lipoprotein tsawg-density (LDL, lossis" phem") qib roj cholesterol thiab koj qib triglyceride.
Monacolin k vs Lovastatin
Lub ntsiab monacolin hauv cov poov xab liab yog monacolin K, uas muaj cov qauv tshuaj tib yam li lovastatin. Txawm hais tias qib ntawm lovastatin sib txawv hauv cov khoom, 2.4 g ntawm cov poov xab liab txhua hnub tuaj yeem muaj txog 4.8 mg ntawm lovastatin, lossis 0.2% ntawm tag nrho cov koob tshuaj.
Rau monacolin k, thov hu rau peb ntawm email:herbext@undersun.com.cn
Tau qhov twg los: https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2018.5368
https://www.nccih.nih.gov/health/red-yeast-rice
https://www.naturalproductsinsider.com/litigation/researchers-find-wide-range-monacolin-k-red-yeast-rice-supplements
https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2018.5368
Tsab ntawv xov xwm no tshwm sim thawj zaug https://www.mayoclinic.org/drugs-supplements-red-yeast-rice/art-20363074
