Cov kev mob tshwm sim ntawm artemisinin
Artemisinin extracttuaj yeem noj tau ntawm qhov ncauj, txhaj rau hauv koj cov leeg, lossis tso rau hauv qhov quav raws li qhov quav. Qhov kev rho tawm no cuam tshuam nrog ob peb yam kev phiv, tab sis nws yuav tsum tsis suav nrog lwm yam tshuaj tshwj tsis yog koj tus kws kho mob pom zoo.
Qee qhov tshwm sim tshwm sim ntawm artemisinin yog:
daim tawv nqaij ua pob
xeev siab
ntuav
tshee
teeb meem daim siab
Koj yuav tsum tsis txhob noj cov tshuaj artemisinin yog tias koj noj tshuaj tiv thaiv qaug dab peg. Nws tuaj yeem ua rau qaug dab peg lossis ua rau cov tshuaj tsis muaj zog. Cov neeg uas muaj teeb meem plab zom mov yuav tsum tsis txhob noj artemisinin.
Artemisinin Cov Teeb Meem Hauv Cov dev
Cov tshuaj anti-malarial artesunate tau qhia txog kev ua haujlwm anticancer hauv vitro thiab hauv kev sim tsiaj ua ntej, tab sis kev paub hauv cov neeg mob qog noj ntshav muaj tsawg heev. Cov kev tshawb fawb ua ntej hauv dev qhia tias mob hnyav ntawm qib ntau npaum li cas. Txoj kev tshawb fawb no txheeb xyuas qhov cuam tshuam ntawm artesunate hauv kab mob qog noj ntshav qog noj ntshav thiab hauv cov neeg mob qog noj ntshav. Plaub kab kab mob canine ntawm tes tau sim hauv vitro txhawm rau nkag siab zoo rau artesunate thiab dihydroartemisinin (DHA; nquag siv metabolite ntawm artesunate). Ib nrab-qhov siab tshaj qhov txwv tsis pub muaj suab thaj (IC50) qhov tseem ceeb rau artesunate lossis DHA yog 2-60 μM hauv peb kab xov tooj, thaum ib kab xovtooj ntawm tes tsis tshua nkag siab rau artesunate (IC50 337 μM) dua li DHA (IC50 50 μM). Kev tshawb fawb thaj chaw nyab xeeb/ua tau zoo nrog artesunate tau ua hauv 23 tus dev nrog cov qog uas tsis tuaj yeem kho tau.
Artesunate tau siv rau 7-385 hnub ntawm qhov ntau npaum ntawm 651-1178 (nruab nrab 922) mg/m2. Tsis tau pom kev mob paj hlwb lossis mob plawv thiab xya tus dev tsis muaj kev cuam tshuam dab tsi hlo li. Ua npaws thiab haematological/mob plab zom mov, feem ntau tsis ntev, tshwm sim hauv 16 tus dev. Ib tug dev tuag los ntawm mob ntsws. Plasma artesunate thiab DHA qib qis dua qhov txwv ntawm kev kuaj pom tsis pub dhau 8-12 teev tom qab kev tswj hwm artesunate, thaum qib tom qab ob teev nyob ze rau 1 μM. Artesunate tau ua tiav qhov kev tshem tawm ntev ntev hauv ib kis mob qog noj ntshav thiab kev ruaj khov mus sij hawm luv ntawm lwm xya qhov xwm txheej.
Artemisinin Side Effects daim siab
Raws li cov ntaub ntawv tshawb fawb tau tshaj tawm thaum Lub Yim Hli 14 qhov teeb meem Kev Mob thiab Mortality Weekly Report, tus txiv neej uas muaj lub siab ua haujlwm ib txwm muaj kev mob plab zuj zus thiab nce ntxiv hauv daim siab enzymes tom qab noj tshuaj ntxiv uas muaj 600 mg ntawm artemisinin rau 10 hnub.
Artemisinin Side Effects lyme disease
Lyme borreliosis yog txuam nrog kev nco tsis zoo. Thaum qhov no tuaj yeem cuam tshuam nrog kev mob hlwb hauv lub cev los ntawm cov kab mob Borrelia, nws kuj tseem tuaj yeem tshwm sim los ntawm kev sib kis los ntawm Babesia protozoa. Anti-malarial artemisinin-derivative artesunate tau pom tias muaj txiaj ntsig zoo rau ntau hom Babesia thiab kom ua tau zoo tiv thaiv tib neeg lub paj hlwb malaria. Peb kwv yees tias kev tswj ua ke ntawm artesunate hauv Lyme borreliosis cov neeg mob yuav pab txo qhov hnyav ntawm tus kheej-qhia txog kev nco lub sijhawm luv. Qhov kev xav no tau sim hauv qhov kev tshawb fawb me me uas cov neeg mob tau kho nrog ob qho tshuaj tua kab mob hauv qhov ncauj thiab qhov ncauj artesunate (20mg plaub zaug hauv ib hnub); kev kho mob tau cuam tshuam nrog kev txo qis qhov hnyav ntawm kev nco lub sij hawm luv (P≃0.08). Hauv qhov pom ntawm cov kev tshawb pom no, peb pom zoo kom ua qhov kev tshawb fawb randomized, tswj cov tshuaj placebo tau kawm.
Puas yog artemisinin nyab xeeb noj?
Artemisinin(hu ua qinghaosu hauv Suav) pom nyob rau hauv nplooj ntawm Artemisia annua (tsob ntoo wormwood qab zib) thiab tau siv ntev los ua tshuaj ntsuab kho mob hauv Suav teb. Txawm hais tias tau siv dav hauv cov tshuaj ntsuab kho mob ntawm Asmeskas cov tuam txhab tsim khoom, txog rau tam sim no artemisinins tsis muaj rau kev siv kho mob hauv Tebchaws Meskas tshwj tsis yog los ntawm CDC raws li kev tshawb nrhiav tshuaj tshiab raws txoj cai (1). Thaum lub Plaub Hlis 2009, kev siv tshuaj artemisinin ua ke, artemether-lumefantnrine (Coartem [Novartis]), tau pom zoo los ntawm Food and Drug Administration (FDA) rau kev kho tus mob npaws.* Artemisinin-muaj cov tshuaj feem ntau suav tias yog nyab xeeb, muaj txiaj ntsig, thiab zoo -tolerated tshuaj rau kev kho tus mob npaws los ntawm P. falciparum uas tsis muaj kev phiv loj (2--4). Txawm hais tias mob siab rau tib neeg tau raug tshaj tawm los ntawm kev noj ntau yam kev npaj tshuaj ntsuab, kev tshawb fawb ntawm cov ntaub ntawv nthuav tawm tsis muaj kev tshaj tawm yav dhau los ntawm kev mob siab rau lub cev los ntawm cov tshuaj ntsuab ntxiv uas muaj artemisinin. Txawm li cas los xij, FDA' Lub Chaw rau Zaub Mov Kev Nyab Xeeb thiab Siv Khoom Noj Khoom Haus muaj cov ntawv ceeb toom ntxiv txog cov xwm txheej tsis zoo cuam tshuam nrog kev noj cov khoom noj uas muaj artemisinin uas muaj cov khoom noj ntxiv uas tsis suav nrog hauv kev tshuaj xyuas no (FDA, cov ntaub ntawv tsis tshaj tawm, 2009).
Puas tuaj yeem noj artemisinin txhua hnub?
Mob caj dab: 150 mg ob zaug ib hnub ntawm Artemisia annua extract tau raug tshuaj xyuas rau 12 lub lis piam hauv kev mob pob txha. Contraindications.
Ntev npaum li cas artemisinin nyob hauv lub cev
Nws yog cov tshuaj sib xyaw ua ke ntawm ob qho khoom xyaw, tsis yog ib qho uas tau pom zoo hauv Asmeskas Ib tus yog artemether, tshuaj lom neeg tsim los ntawm artemisinin, rho tawm los ntawm tsob ntoo wormwood qab zib uas tau siv hauv tshuaj Suav ua kub taub hau rau 500 lossis 600 xyoo . Artemether nyob hauv lub cev tau peb hnub.
Rau bulkArtemisinin, tiv tauj peb ntawm email:herbext@undersun.com.cn
Cov ntaub ntawv: https: //www.medpagetoday.com/gastroenterology/hepatitis/15523
https://www.healthline.com/health/artemisinin-cancer#side-effects
https://ar.iiarjournals.org/content/33/5/1819
https://pubmed.ncbi.nlm.nih.gov/28735651/
https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5831a3.htm
https://www.scientificamerican.com/article/artemisinin-coartem-malaria-novartis/
