Artemisinin Dosage rau Cancer
Qhov tshwj xeeb npaum li cas rau qhov ua tau zoo tshaj plaws tseem tsis tau tsim; Txawm li cas los xij, raws li txoj cai dav dav, 400 txog 800 mg ib hnub tuaj yeem siv tau tsawg kawg rau rau rau 12 lub hlis, tsis pom muaj qhov cuam tshuam zoo li cas.
Artemisinintsis muaj qhov sib xyaw muaj txiaj ntsig los tiv thaiv mob qog noj ntshav thiab nws qhov ua tau zoo tau txhim kho los ntawm qhov tseeb tias nws muaj txiaj ntsig zoo ntawm qhov ncauj thiab pheej yig, piv rau lwm qhov kev cuam tshuam tshuaj muaj nyob hauv khw. Nws ua rau muaj kev phom sij tsawg dua, uas ua rau nws muaj txiaj ntsig zoo rau kev kho mob hauv cov chaw tau nyiaj tsawg uas qhov mob qog noj ntshav muaj cov hauv paus hniav, feem ntau yog vim kev kho mob kim thiab tsis txaus siab xaiv rau txoj cai ib txwm muaj rau kev mob qog noj ntshav [3]. Tsis tas li ntawd, kev tshawb fawb tsis ntev los no los ntawm Lin Qingsong li al. pom tias qhov sib ntxiv ntawm aminolevulinic acid (ALA) txhim kho cov tshuaj tiv thaiv kab mob qog noj ntshav ntawm artemisinin tiv thaiv kab mob qog noj ntshav ntawm txoj hnyuv [4]. Yog li, yog tias lub hom phiaj phiaj xwm tau tsim los tsim cov tshuaj artemisinin los ua txuas ntxiv los siv hauv kev kho mob qog noj ntshav, nws yuav ua rau txo nqi nyiaj txiag rau kev kho mob kho mob. Muab tias ntau dua 25 hom artemisinin tau pom hauv Pakistan [5], kws kho mob oncologists hauv Pakistan yuav tsum ua kom zoo dua ntawm cov tshuaj no thiab tshawb nrhiav nws cov txiaj ntsig hauv kev kho mob qog noj ntshav ntau yam.
Artemisinin Dosage rau Cancer hauv dev
Osteosarcoma yog cov mob qog nqaij hlav pob txha feem ntau tshwm sim hauv cov dev. Kwv yees li ntawm 10,000 tus dev nyob hauv ib xyoos hauv Tebchaws Meskas. Ntau qhov loj-rau cov tsiaj loj yog muaj kev pheej hmoo ntxiv rau osteosarcoma. Tsis ntev los no, kev sib tw so haujlwm Greyhound tau tshaj tawm tias yog qhov muaj kev pheej hmoo siab tshaj plaws. Artemisinin yog ib yam tshuaj uas tau siv tsis tu ncua hauv cov dev nrog osteosaroma. Keeb kwm, nws tau siv rau kev kho mob malaria hauv South Asia, tab sis nws kuj tua cov qog nqaij hlav cancer vim yog cov dawb radical tsim nyob rau hauv cov tshuaj tiv thaiv nruab nrab los ntawm hlau. Cov qog nqaij hlav qog noj ntshav muaj cov hlau ntau dua li cov qog ib txwm, yog li artemisinin yog qhov tshuaj lom.
Artemisinin extractthiab nws cov analogs ua tau zoo hauv ntau hom tib neeg cov qog nqaij hlav cancer hauv cov raj kuaj. Peb tau pom yav dhau los tias qis qis ntawm artemisinin derivatives ua rau cov cell tuag hauv ntau hom canine qog noj ntshav hauv cov raj kuaj. Artemisinin thiab nws cov analogs tau siv hauv kev kho mob qog noj ntshav hauv tib neeg, thiab hauv cov dev nrog osteosarcoma, nrog kev tswj hwm niaj hnub ntawm koob tshuaj me me; txawm li cas los xij, muaj qee qhov kev ceeb toom ntawm kev ua tiav. Qhov txo qis ntawm lub plab nqus ntawm artemisinin tshwm sim nyob rau hauv hnub yog tias nws tau muab txhua hnub. Peb xav tias qhov siab, mem tes-koob tshuaj artemisinin yuav muaj kev nyab xeeb thiab muaj txiaj ntsig zoo hauv kev kho mob qog noj ntshav vim tias nws tsis zoo li yuav ua rau nqus tau nqus thiab nws tuaj yeem ua tiav cov ntshav ntau dua.
Lub tswv yim no tau ua rau txhawb nqa cov lus teb kho mob tsawg tus dev nrog mob qog noj ntshav hauv peb lub tsev kho mob. Txoj kev tshawb fawb no yuav tshawb xyuas yog tias kev nqus tau tuaj yeem zam tau los ntawm kev siv tshuaj mem tes-artemisinin, thiab kev nyab xeeb ntawm kev siv tshuaj artemisinin ntau hauv dev. Cov ntaub ntawv ntawm txoj kev tshawb fawb no yog qhov tseem ceeb txhawm rau tsim kev sim tshuaj kho mob ntxiv rau kev kho mob qog noj ntshav siv cov pab pawg cog lus no.
Artemisinin Dosage rau Cancer Cancer
Artemisinin, cov khoom sib cais los ntawm cov txiv hmab txiv ntoo qab zib Artemisia annua L., yav tas los tau pom tias muaj kev xaiv tshuaj lom rau cov qog nqaij hlav cancer hauv vitro. Hauv qhov kev sim tam sim no, peb tau kawm txog qhov muaj peev xwm ntawm artemisinin los tiv thaiv kev txhim kho mob qog noj ntshav hauv cov nas kho nrog ib koob tshuaj ib zaug (50mg/kg) ntawm 7,12-dimethylbenz [a] anthracene (DMBA), paub ua kom muaj qog ntau lub mis. Pib txij hnub tam sim tom qab kev kho mob DMBA, ib pab pawg nas tau muab cov hmoov ua hmoov-chow uas muaj 0.02% artemisinin, hos pab pawg tswj hwm tau muab zaub mov ua hmoov dawb. Rau 40 lub lis piam, ob pawg nas tau raug tshuaj xyuas rau cov qog nqaij hlav hauv lub mis.
Artemisinin Dosage COVID
SARS-CoV-2 ncaj qha kis mus rau endothelium thiab ua rau muaj kev tiv thaiv kab mob hauv lub cev uas ua rau muaj kev ua haujlwm tsis txaus endothelial thiab apoptosis. Cov kev tshwm sim no ua rau cov ntshav khov ntau dua thiab ua rau muaj kev tsim cov hlab ntshav [34]. Raws li kev tshawb fawb, cov neeg laus txhaj tshuaj AP rau tus mob npaws npaws suav nrog plaub ntsiav tshuaj (artemisinin 250 mg thiab piperaquine 1500 mg), uas tau qhia ntev QT-ntu nyob hauv qee tus neeg [35].
Tag nrho pom zoo AP cov neeg laus rau kev kho COVID-19 muaj yim ntsiav tshuaj (artemisinin 500 mg thiab piperaquine 3000 mg). Txoj kev tshawb fawb tam sim no pom muaj kev ncua ntev hauv ob tus neeg mob (11.76%) thiab qhov sib txawv tseem ceeb ntawm ob pab pawg. Txawm hais tias kev kho mob AP tuaj yeem ua rau QT ncua sijhawm ntev hauv qee tus neeg mob, nws tsis ua rau TdP lossis lwm yam kev mob plawv tsis zoo. Ntxiv mus, cov neeg mob uas ncua sijhawm QT tau rov zoo li qub tom qab siv tshuaj lawm. Txawm li cas los xij, txiav txim siab qhov tshwm sim ntawm SARS-CoV-2 ntawm cov hlab ntsha thiab cov kev mob tshwm sim ntawm AP, kaw kev saib xyuas QT ntu hloov pauv thaum kho AP tseem pom zoo.
Txog rau ntau artemisinin, thov hu rau peb ntawm email:herbext@undersun.com.cn
Cov ntaub ntawv: https: //www.ncbi.nlm.nih.gov/pmc/articles/PMC6347441/
https://www.akcchf.org/research/research-portfolio/0841.html
https://pubmed.ncbi.nlm.nih.gov/16356830/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605811/
